The flight
LATAM dominates this route with multiple daily frequencies. About 2 hours 20 minutes, making it one of South America’s busiest air corridors. Aerolineas Argentinas also operates the route with less frequency.
Key logistics: This route departs from Aeroparque (AEP) in Buenos Aires, not Ezeiza. AEP is only 15 minutes from central Buenos Aires, making it a much easier departure than Ezeiza. In Santiago, you arrive at SCL, 30-45 minutes west of the city centre.
Book direct through LATAM for the simplest experience. Fares are competitive and availability is rarely an issue on a route this busy.
The Andes crossing
This is the reason to pay attention. On a clear day, the views from a window seat are extraordinary. Snow-covered peaks, glaciers, and mountain valleys stretching to the horizon. Book a window seat on the right side heading westbound (Buenos Aires to Santiago) for the best perspective.
Turbulence crossing the Andes is common and sometimes significant. The seatbelt sign comes on for a reason. This is completely normal for the route and pilots handle it routinely. If turbulence makes you nervous, know what to expect.
The descent into Santiago is dramatic, with the city appearing suddenly against the mountain backdrop.
The service
Drinks only - no meal service on this short hop. A cart passes through with water, soft drinks, and juice. Eat before you board or bring something. The seat is standard short-haul economy, adequate for two hours. See my LATAM Buenos Aires to Santiago review for the full assessment.
The bus alternative
Yes, you can bus across the Andes between Buenos Aires and Santiago. Multiple companies operate the route, taking 20-22 hours through the Paso Los Libertadores mountain crossing. It is significantly cheaper than flying and the scenery through the mountain pass is spectacular. But it is a full day of travel, the road can close in winter due to snow, and the journey is exhausting. This is an experience rather than practical transport. For most travellers, the flight is the right choice.
Airport logistics
In Buenos Aires: Aeroparque’s international departure area is small and functional. Arrive two hours before and you will have time to spare. Limited food options and a compact duty free. See my Aeroparque transfer guide for getting to AEP.
In Santiago: SCL is a larger airport with more facilities. Immigration is quick (5-10 minutes on my experience). See my SCL transfer guide for getting into Santiago, and my Santiago airport guide for terminal details.
Cross-links
This route connects two of South America’s great capitals. For destination planning: